Once the epidemic struck, there was no turning back, and Byzantine culture began to lose some of its dominance. Other deadly pandemics soon followed. The Plague of Cyprian’s beginnings are unknown, but it ravaged the Roman Empire in the third century.
Then there was the bubonic plague, which was a predecessor of the Black Death in Europe. While Justinian was expanding his domain in the hopes of making it greater and more strong than ever, roughly half of his citizens died of Yersinia pestis, a little bacteria. The outbreak most likely entered the empire via one of the empire’s primary trade routes.